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Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection

6 Jun 2006

Abstract excerpt

Like other DNA viruses, herpes simplex virus type 1 (HSV-1) interacts with components of the cellular response to DNA damage. For example, HSV-1 sequesters endogenous, uninduced, hyperphosphorylated RPA (replication protein A) away from viral replication compartments. RPA is a ssDNA-binding protein that signals genotoxic stress through the ATR (ataxia telangiectasia-mutated and Rad3-related) pathway. The...

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PMID: 16757521
DOI: 10.1242/jcs.02981

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