Article

New Drosophila models to uncover the intrinsic and extrinsic factors mediating the toxicity of the human prion protein

2021-06-25

Abstract excerpt

Misfolded conformations of the prion protein (PrP) are responsible for devastating neurological disorders in humans and mammals. An unresolved problem is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular mechanism leading to neurodegeneration. The variable susceptibility of mammals to prion diseases can be exploited to understand the conformational dynamics of PrP. Here...

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Literature Corpus work: cc5b01e1-3505-53d3-8913-8152e8552dd5
DOI: 10.1101/2021.06.24.449794

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