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Article

Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.

Human molecular genetics - 1 Nov 2013

Sanchez-Garcia Jonatan, Arbelaez Daniela, Jensen Kurt, Rincon-Limas Diego E, Fernandez-Funez Pedro

Abstract excerpt

Prion diseases encompass a diverse group of neurodegenerative conditions characterized by the accumulation of misfolded prion protein (PrP) isoforms. Other conformational variants of PrP have also been proposed to contribute to neurotoxicity in prion diseases, including misfolded intermediates as well as cytosolic and transmembrane isoforms. To better understand PrP neurotoxicity, we analyzed the role of two...

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Identifiers

PMID: 23771030
DOI: 10.1093/hmg/ddt276
PMCID: PMC3792687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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