Article
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.
Cell - 17 Apr 1998
Shmerling D, Hegyi I, Fischer M, Blättler T, Brandner S, Götz J, Rülicke T, Flechsig E, Cozzio A, von Mering C, Hangartner C, Aguzzi A, Weissmann C
Abstract excerpt
The physiological role of prion protein (PrP) remains unknown. Mice devoid of PrP develop normally but are resistant to scrapie; introduction of a PrP transgene restores susceptibility to the disease. To identify the regions of PrP necessary for this activity, we prepared PrP knockout mice expres...
Topics
- Alleles
- Animals
- Ataxia
- Brain Chemistry
- Cell Death
- Cerebellum
- Genes
- Mice
- Mice, Transgenic
- Neurons
- Phenotype
- Prions
- RNA, Messenger
- Scrapie
- Sequence Deletion
- Time Factors