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Article

The effective opening of nicotinic acetylcholine receptors with single agonist binding sites.

The Journal of general physiology - 1 Apr 2011

Williams Dustin K, Stokes Clare, Horenstein Nicole A, Papke Roger L

Abstract excerpt

We have identified a means by which agonist-evoked responses of nicotinic receptors can be conditionally eliminated. Modification of α7L119C mutants by the sulfhydryl reagent 2-aminoethyl methanethiosulfonate (MTSEA) reduces responses to acetylcholine (ACh) by more than 97%, whereas corresponding mutations in muscle-type receptors produce effects that depend on the specific subunits mutated and ACh concentration....

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Identifiers

PMID: 21444659
DOI: 10.1085/jgp.201010587
PMCID: PMC3068282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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