Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response.

doi:10.1111/j.1469-7793.1998.655ba.x

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Article

Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response.

The Journal of physiology - 15 Dec 1998

Figl A, Viseshakul N, Shafaee N, Forsayeth J, Cohen B N

Abstract excerpt

1. We constructed rat homologues (S252F and +L264) of two human alpha4 nicotinic mutations - alpha4(S248F) and alpha4(777ins3) - that have been linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and co-expressed them with wild-type rat beta2 subunits in Xenopus oocytes. 2. The...

Topics

Algorithms
Animals
Bridged Bicyclo Compounds, Heterocyclic
Calcium
Electric Stimulation
Electrophysiology
Epilepsy, Frontal Lobe
Humans
Iodine Radioisotopes
Ion Channels
Membrane Potentials
Mutation
Nicotinic Agonists
Oocytes
Patch-Clamp Techniques
Pyridines
Rats
Receptors, Nicotinic

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Identifiers

PMID: 9824708
DOI: 10.1111/j.1469-7793.1998.655ba.x
PMCID: PMC2231326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9824708-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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