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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

Cell - 22 Aug 2003

Wu Shian, Huang Jianbin, Dong Jixin, Pan Duojia

Abstract excerpt

The coordination between cell proliferation and cell death is essential to maintain homeostasis within multicellular organisms. The mechanisms underlying this regulation are yet to be completely understood. Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila. hpo encodes a Ste-20 family protein kinase that binds to and phosphorylates the...

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Identifiers

PMID: 12941273
DOI: 10.1016/s0092-8674(03)00549-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.PMID 12941273Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

Coupling cell growth, proliferation, and death. Hippo weighs in.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.Semantic proximity Read ↗

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.Semantic proximity Read ↗

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