Article
Human leucocyte antigen alleles and haplotypes and their associations with antinuclear antibodies features in Chinese patients with primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2014
Zhao Dan-Tong, Liao Hui-Yu, Zhang Xin, Liu Yan-Min, Zhao Yan, Zhang Hai-Ping, Sun Li-Mei, Ma Yin-Xue, Yan Hui-Ping
Abstract excerpt
BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is an autoimmune liver disease. Genetic factors are critical in determining susceptibility to PBC. Among human leuocyte antigen (HLA) genes, an association between the DRB1*08 allele and PBC has been reported in many populations, but not in Chinese patients. METHODS: We investigated HLA-A, B, DRB1, and DQB1 alleles and haplotypes in 145 PBC patients and 500...
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