Article
Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected].
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2012
Lang Kuhs Krystle A, Ginsberg Arielle A, Yan Jian, Wiseman Roger W, Khan Amir S, Sardesai Niranjan Y, O'Connor David H, Weiner David B
Abstract excerpt
Numerous studies have suggested that an effective hepatitis C virus (HCV) vaccine must induce a strong T helper 1 (Th1) T cell response. While several therapeutic vaccine candidates have shown promise in clinical trials, response rates have been low suggesting that further optimization is important. However, such optimization has been hindered by a lack of a benchmark animal model in which to test vaccine-induced...
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