Article

Immunoglobin and T cell receptor repertoire changes induced by a prototype vaccine against Chagas disease in naïve rhesus macaques

2023-11-02

Abstract excerpt

<title>Abstract</title> <p>A vaccine against Trypanosoma cruzi, the agent of Chagas disease, would be an excellent additional tool for disease control. A recombinant vaccine based on Tc24 and TSA1 parasite antigens was found to be safe and immunogenic in naïve macaques. Here we performed a transcriptomic analysis of PBMC responses to vaccination, to shed light on the immunogenicity of this vaccine and guide the o...

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Literature Corpus work: 6aa8a8c0-7115-5c07-8886-d434370c0f00
DOI: 10.21203/rs.3.rs-3453582/v1

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