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Article

Immunization With a Subunit Hepatitis C Virus Vaccine Elicits Pan-Genotypic Neutralizing Antibodies and Intrahepatic T-Cell Responses in Nonhuman Primates.

The Journal of infectious diseases - 15 Jun 2017

Li Dapeng, Wang Xuesong, von Schaewen Markus, Tao Wanyin, Zhang Yunfang, Heller Brigitte, Hrebikova Gabriela, Deng Qiang, Sun Qiang, Ploss Alexander, Zhong Jin, Huang Zhong

Abstract excerpt

Background: The global control of hepatitis C virus (HCV) infection remains a great burden, owing to the high prices and potential drug resistance of the new direct-acting antivirals (DAAs), as well as the risk of reinfection in DAA-cured patients. Thus, a prophylactic vaccine for HCV is of great importance. We previously reported that a single recombinant soluble E2 (sE2) vaccine produced in insect cells was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28398489
DOI: 10.1093/infdis/jix180
PMCID: PMC5853543

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