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Article

Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo.

Respiratory research - 22 Dec 2015

Kunz L I Z, van't Wout E F A, van Schadewijk A, Postma D S, Kerstjens H A M, Sterk P J, Hiemstra P S

Abstract excerpt

BACKGROUND: Macrophages constitute a heterogeneous cell population with pro- (MΦ1) and anti-inflammatory (MΦ2) cells. The soluble chitinase-like-protein YKL-40 is expressed in macrophages and various other cell types, and has been linked to a variety of inflammatory diseases, including COPD. Dexamethasone strongly reduces YKL-40 expression in peripheral blood mononuclear cells (PBMC) in vitro. We hypothesized...

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Identifiers

PMID: 26696093
DOI: 10.1186/s12931-015-0314-3
PMCID: PMC4699377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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