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Article

Impaired resistance to infection does not increase the virulence of Salmonella htrA live vaccines for mice.

Microbial pathogenesis - 1 Apr 1992

Strahan K, Chatfield S N, Tite J, Dougan G, Hormaeche C E

Abstract excerpt

We have described a new class of live attenuated salmonella vaccines harbouring lesions in htrA, a stress protein gene previously. The virulence and invasiveness of Salmonella htrA mutants was investigated in three models of increased susceptibility to Salmonella infection. These included BALB/c mice, either given sublethal whole body irradiation (350 R) or administered rabbit anti-TNF alpha antiserum, and...

Topics

Animals
Bacterial Vaccines
Female
Genes, Bacterial
Immunity, Innate
Kinetics
Male
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Mutation
Salmonella

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella Infections, Animal

Tumor Necrosis Factor-alpha

Vaccines, Attenuated

Virulence

Whole-Body Irradiation

Source

Identifiers

PMID: 1630300
DOI: 10.1016/0882-4010(92)90049-t

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1630300-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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