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Article

Live Attenuated S. Typhimurium Vaccine with Improved Safety in Immuno-Compromised Mice

24 Sept 2012

Abstract excerpt

Live attenuated vaccines are of great value for preventing infectious diseases. They represent a delicate compromise between sufficient colonization-mediated adaptive immunity and minimizing the risk for infection by the vaccine strain itself. Immune defects can predispose to vaccine strain infections. It has remained unclear whether vaccine safety could be improved via mutations attenuating a vaccine in...

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PMID: 23029007
DOI: 10.1371/journal.pone.0045433

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