c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma.

doi:10.1016/0016-5085(90)91024-z

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Article

c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma.

Gastroenterology - 1 Aug 1990

Burmer G C, Levine D S, Kulander B G, Haggitt R C, Rubin C E, Rabinovitch P S

Abstract excerpt

Mutations in the first exon of the c-Ki-ras protooncogene were analyzed in carcinomas and dysplasias from patients with sporadic colon cancer and chronic ulcerative colitis by a combination of histological enrichment, cell sorting, polymerase catalyzed chain reaction, and direct sequencing. In co...

Topics

Adult
Aged
Aneuploidy
Cell Separation
Colitis, Ulcerative
Colonic Neoplasms
Female
Flow Cytometry
Genes, ras
Humans
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Proto-Oncogenes

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