Article
Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma.
Environmental health perspectives - 1 Jun 1991
Burmer G C, Rabinovitch P S, Loeb L A
Abstract excerpt
Sporadic colon carcinomas, carcinomas arising in chronic ulcerative colitis, and pancreatic adenocarcinomas have been analyzed for the presence of c-Ki-ras mutations by a combination of histological enrichment, cell sorting, polymerase chain reaction, and direct sequencing. Although 60% (37/61) o...
Topics
- Adenocarcinoma
- Aneuploidy
- Carcinoma
- Codon
- Colitis, Ulcerative
- Colon
- Colonic Neoplasms
- DNA Damage
- DNA Mutational Analysis
- DNA, Neoplasm
- Flow Cytometry
- Genes, ras
- Humans
- Mutation
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogene Proteins p21(ras)