c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis.

doi:10.1016/0016-5085(92)90323-q

Back to search

Article

c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis.

Gastroenterology - 1 Jun 1992

Chen J, Compton C, Cheng E, Fromowitz F, Viola M V

Abstract excerpt

A sensitive restriction fragment length polymorphism assay and DNA sequencing were used to detect c-Ki-ras mutations in 56 specimens of colonic epithelium from 18 patients with chronic ulcerative colitis. Mutations were not detected in biopsy specimens that were negative or indefinite for dysplas...

Topics

Base Sequence
Colitis, Ulcerative
Colonic Neoplasms
Genes, ras
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Precancerous Conditions

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.