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Article

c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis.

Gastroenterology - 1 Jun 1992

Chen J, Compton C, Cheng E, Fromowitz F, Viola M V

Abstract excerpt

A sensitive restriction fragment length polymorphism assay and DNA sequencing were used to detect c-Ki-ras mutations in 56 specimens of colonic epithelium from 18 patients with chronic ulcerative colitis. Mutations were not detected in biopsy specimens that were negative or indefinite for dysplasia. In 4 of 8 patients with high-grade dysplasia, a c-Ki-ras codon 12 or 13 mutation was detected. In three colectomy...

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Identifiers

PMID: 1350261
DOI: 10.1016/0016-5085(92)90323-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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