Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.

doi:10.1002/(sici)1097-0215(19980330)76:1<1::aid-ijc1>3.0.co;2-4

Article

Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.

International journal of cancer - 30 Mar 1998

Holzmann K, Klump B, Borchard F, Hsieh C J, Kühn A, Gaco V, Gregor M, Porschen R

Abstract excerpt

Neoplastic progression in patients with chronic ulcerative colitis is characterized by the development of epithelial dysplasia, which is accompanied by genetic alterations. This study determined the time of onset of p53 and Ki-ras mutations as well as DNA aneuploidy during histological progressio...

Topics

Aneuploidy
Cell Transformation, Neoplastic
Colectomy
Colitis, Ulcerative
Colonic Neoplasms
DNA, Neoplasm
Disease Progression
Genes, p53
Genes, ras
Humans
Mutation
Precancerous Conditions

Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.

Abstract excerpt

Topics

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