Article
Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
Gastroenterology - 1 Feb 1995
Redston M S, Papadopoulos N, Caldas C, Kinzler K W, Kern S E
Abstract excerpt
BACKGROUND/AIMS: Chronic colitis is associated with an increased risk of colorectal neoplasia, creating a need for early diagnosis in this population. Little is yet known of the genetic changes of early lesions. Cases of colitis-associated neoplasia were analyzed for APC and K-ras mutations with special emphasis given to the spectrum of noninvasive lesions. METHODS: Ten patients were studied. APC mutations were...
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