Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.

doi:10.1016/0016-5085(95)90064-0

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Article

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.

Gastroenterology - 1 Feb 1995

Redston M S, Papadopoulos N, Caldas C, Kinzler K W, Kern S E

Abstract excerpt

BACKGROUND/AIMS: Chronic colitis is associated with an increased risk of colorectal neoplasia, creating a need for early diagnosis in this population. Little is yet known of the genetic changes of early lesions. Cases of colitis-associated neoplasia were analyzed for APC and K-ras mutations with...

Topics

Adult
Aged
Base Sequence
Colitis
Colonic Neoplasms
Genes, APC
Genes, ras
Humans
Middle Aged
Molecular Sequence Data
Mutation
Precancerous Conditions

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