Article
Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey.
Genetics and molecular research : GMR - 9 Sept 2011
Yilmaz M B, Pazarbasi A, Guzel A I, Kocaturk-Sel S, Kasap H, Kasap M, Urunsak I F, Basaran S, Alptekin D, Demirhan O
Abstract excerpt
Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two common polymorphisms, in the promoter region (T→C substitution) of CYP17 and exon 3...
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