Article
CYP19A1 polymorphisms are associated with bone mineral density in Chinese men.
Human genetics - 1 May 2007
Hong Xiumei, Hsu Yi-Hsiang, Terwedow Henry, Arguelles Lester M, Tang Genfu, Liu Xue, Zhang Shanchun, Xu Xin, Xu Xiping
Abstract excerpt
Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls...
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