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Article

SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

1 Nov 2013

Abstract excerpt

SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and migration. We found that SHARPIN localizes to the trailing edges (uropods) of both mouse and human chemokine-activated lymphocytes migrating on intercellular adhesion molecule-1 (ICAM-1), which is one of the major...

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PMID: 24210817
DOI: 10.1016/j.celrep.2013.10.011

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