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Article

Effect of a partial loss of function MC3R mutation on MC3R+GHSR-1A heterodimer activity and RNF11 regulation.

Journal of endocrinological investigation - 1 Apr 2026

Durhan S T, Yanovski J A, Ozcubukcu S, Yanik T

Abstract excerpt

PURPOSE: The melanocortin 3 receptor (MC3R) is a G-protein coupled receptor that has been identified as a regulator of energy balance mechanisms. In addition to its role in weight gain and appetite regulation mechanisms, recent studies have shown that MC3R is important for growth, puberty, circadian rhythms, and liver autophagy. In human populations, loss-of-function mutations of MC3R, particularly the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41410731
DOI: 10.1007/s40618-025-02774-3
PMCID: PMC13215352

Genes

MC3R
RNF11
GHSR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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