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Article

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.

International journal of molecular sciences - 12 Feb 2020

Paisdzior Sarah, Dimitriou Ioanna Maria, Schöpe Paul Curtis, Annibale Paolo, Scheerer Patrick, Krude Heiko, Lohse Martin J, Biebermann Heike, Kühnen Peter

Abstract excerpt

The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity, which appears to be mediated by changes in the anorectic action of MC4R via GS-dependent cyclic adenosine-monophosphate (cAMP) signaling as well as other...

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Identifiers

PMID: 32059383
DOI: 10.3390/ijms21041224
PMCID: PMC7072973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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