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Article

Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer.

Oncogene - 19 May 2005

Jones Laundette P, Li Minglin, Halama Ewa D, Ma Yongxian, Lubet Ronald, Grubbs Clinton J, Deng Chu-Xia, Rosen Eliot M, Furth Priscilla A

Abstract excerpt

Loss of full-length Brca1 in mammary epithelial cells of the mouse mammary tumor virus (MMTV)-Cre Brca1 conditional exon 11 deletion mouse model results in the development of mammary adenocarcinomas with similar genetic changes to those found in human BRCA1-mutation-related breast cancers. We used this experimental model to evaluate the chemopreventive effect of tamoxifen on the development of mammary...

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Share to Antineoplastic Agents, Hormonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15750629
DOI: 10.1038/sj.onc.1208426

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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