Article
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008
Shakya Reena, Szabolcs Matthias, McCarthy Ellen, Ospina Elson, Basso Katia, Nandula Subhadra, Murty Vundavalli, Baer Richard, Ludwig Thomas
Abstract excerpt
Women with germ-line mutations of the BRCA1 tumor suppressor gene are highly susceptible to breast and ovarian cancer. The protein product of BRCA1 is involved in a broad spectrum of biological processes and interacts with many diverse proteins. One of these, BARD1, associates with BRCA1 to form a heterodimeric complex that is enzymatically active as an ubiquitin E3 ligase. Although the BRCA1/BARD1 heterodimer...
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