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Article

CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.

Cancer prevention research (Philadelphia, Pa.) - 1 Mar 2011

Kim Eun-Hee, Deng Chu-Xia, Sporn Michael B, Liby Karen T

Abstract excerpt

Breast cancer-associated gene 1 (BRCA1) protein plays important roles in DNA damage and repair, homologous recombination, cell-cycle regulation, and apoptosis. The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Imidazolide, CDDO-Im) is a promising anticance...

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Source

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Identifiers

PMID: 21372041
DOI: 10.1158/1940-6207.CAPR-10-0153
PMCID: PMC3076712

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21372041-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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