Article
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.
PLoS genetics - 1 Jan 2015
Demirkan Ayşe, Henneman Peter, Verhoeven Aswin, Dharuri Harish, Amin Najaf, van Klinken Jan Bert, Karssen Lennart C, de Vries Boukje, Meissner Axel, Göraler Sibel, van den Maagdenberg Arn M J M, Deelder André M, C 't Hoen Peter A, van Duijn Cornelia M, van Dijk Ko Willems
Abstract excerpt
Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitative traits in serum, followed by exome sequence analysis to zoom in on putative causal variants in the associated...
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