Article
A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2020
Alic Lejla, Papac-Milicevic Nikolina, Czamara Darina, Rudnick Ramona B, Ozsvar-Kozma Maria, Hartmann Andrea, Gurbisz Michael, Hoermann Gregor, Haslinger-Hutter Stefanie, Zipfel Peter F, Skerka Christine, Binder Elisabeth B, Binder Christoph J
Abstract excerpt
Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like protein 1 (FHL-1) to self-ligands or altered self-ligands (e.g., malondialdehyde [MDA]-modified molecules) involved in...
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