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Article

Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration.

Investigative ophthalmology & visual science - 1 May 2008

Ormsby Rebecca J, Ranganathan Shoba, Tong Joo Chuan, Griggs Kim M, Dimasi David P, Hewitt Alex W, Burdon Kathryn P, Craig Jamie E, Hoh Josephine, Gordon David L

Abstract excerpt

PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD). The purpose of this study was to understand how the Y402H variant in FH/FHL-1 contributes to the pathogenesis of AMD and, in particular, whether interactions mediated by FH/FHL-1, including binding to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18263814
DOI: 10.1167/iovs.07-1297

Genes

CRP
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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