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Article

Y402H Polymorphism of Complement Factor H Affects Binding Affinity to C-Reactive Protein

1 Mar 2007

Abstract excerpt

Complement factor H (FH) is an important regulator of the alternative complement pathway. The Y402H polymorphism within the seventh short consensus repeat of FH was recently shown to be associated with age-related macular degeneration, the most common cause of irreversible blindness in the Western world. We examined the effects of this polymorphism on various FH functions. FH purified from sera of age-related...

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Complement system in diseases
Protease and Inhibitor Mechanisms
Retinal Diseases and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17339482
DOI: 10.4049/jimmunol.178.6.3831

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