Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Y402H Polymorphism of Complement Factor H Affects Binding Affinity to C-Reactive Protein

1 Mar 2007

Abstract excerpt

Complement factor H (FH) is an important regulator of the alternative complement pathway. The Y402H polymorphism within the seventh short consensus repeat of FH was recently shown to be associated with age-related macular degeneration, the most common cause of irreversible blindness in the Western world. We examined the effects of this polymorphism on various FH functions. FH purified from sera of age-related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Protease and Inhibitor Mechanisms
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17339482
DOI: 10.4049/jimmunol.178.6.3831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Y402H Polymorphism of Complement Factor H Affects Binding Affinity to C-Reactive ProteinPMID 17339482Read ↗

Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration.Semantic proximity Read ↗

Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular DegenerationSemantic proximity Read ↗

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Semantic proximity Read ↗

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.Semantic proximity Read ↗

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.Semantic proximity Read ↗

Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

Biochemical analysis of a common human polymorphism associated with age-related macular degeneration.Semantic proximity Read ↗

Structural basis for complement factor H linked age-related macular degeneration.Semantic proximity Read ↗

The Factor H Variant Associated with Age-related Macular Degeneration (His-384) and the Non-disease-associated Form Bind Differentially to C-reactive Protein, Fibromodulin, DNA, and Necrotic CellsSemantic proximity Read ↗

Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant.Semantic proximity Read ↗

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Semantic proximity Read ↗

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.