Article
TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain.
Nature communications - 18 Apr 2018
Wang Yan, Gao Yingwei, Tian Quan, Deng Qi, Wang Yangbo, Zhou Tian, Liu Qiang, Mei Kaidi, Wang Yingping, Liu Huiqing, Ma Ruining, Ding Yuqiang, Rong Weifang, Cheng Jinke, Yao Jing, Xu Tian-Le, Zhu Michael X, Li Yong
Abstract excerpt
Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carrageenan- and Complete Freund's adjuvant-induced inflammation models. TRPV1 is SUMOylated at a C-terminal Lys residue...
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