Article
Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels.
The Journal of physiology - 15 Aug 2010
Kolbe Katrin, Schönherr Roland, Gessner Guido, Sahoo Nirakar, Hoshi Toshinori, Heinemann Stefan H
Abstract excerpt
Excess reactive oxygen species (ROS) play a crucial role under pathophysiological conditions, such as ischaemia/reperfusion and diabetes, potentially contributing to cardiac arrhythmia. hERG1 (KCNH2) potassium channels terminate the cardiac action potential and malfunction can lead to long-QT syndrome and fatal arrhythmia. To investigate the molecular mechanisms of hERG1 channel alteration by ROS, hERG1 and...
Topics
- Cell Line
- Cysteine
- Ether-A-Go-Go Potassium Channels
- Glucose
- Humans
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Oxidants
- Oxidation-Reduction
- Oxidative Stress