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Article

Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2008

Tennese Alysa A, Gee Christopher B, Wevrick Rachel

Abstract excerpt

Prader-Willi syndrome is a neurodevelopmental disorder marked by abnormalities in feeding, drinking, thermoregulation, intestinal motility, and reproduction, suggesting disruption of the autonomic nervous system. Necdin, one of several proteins genetically inactivated in individuals with Prader-Willi syndrome, is important for the differentiation of central and sensory neurons. We now show that formation,...

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Identifiers

PMID: 18570257
DOI: 10.1002/dvdy.21615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons.PMID 18570257Read ↗

Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during developmentSemantic proximity Read ↗

Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.Semantic proximity Read ↗

The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal regionSemantic proximity Read ↗

Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1.Semantic proximity Read ↗

The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.Semantic proximity Read ↗

NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.Semantic proximity Read ↗

Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.Semantic proximity Read ↗

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and MouseSemantic proximity Read ↗

Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndromeSemantic proximity Read ↗

Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.Semantic proximity Read ↗

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.Semantic proximity Read ↗

Dicer is required for survival of differentiating neural crest cells.Semantic proximity Read ↗

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