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Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain.

PloS one - 1 Jan 2015

Jarrar Wassan, Dias Jose M, Ericson Johan, Arnold Hans-Henning, Holz Andreas

Abstract excerpt

Cranial motor nerves in vertebrates are comprised of the three principal subtypes of branchial, visceral, and somatic motor neurons, which develop in typical patterns along the anteroposterior and dorsoventral axes of hindbrain. Here we demonstrate that the formation of branchial and visceral motor neurons critically depends on the transcription factors Nkx2.2 and Nkx2.9, which together determine the cell fate of...

Topics

Animals
Axons
Body Patterning
Cell Count
Cell Lineage
Embryo, Mammalian
Homeobox Protein Nkx-2.2
Homeodomain Proteins
Mice, Knockout
Motor Neurons
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rhombencephalon

Transcription Factors

Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25919494
DOI: 10.1371/journal.pone.0124408
PMCID: PMC4412715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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