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Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2 (LRRK2) for Parkinson's disease.

Parkinsonism & related disorders - 1 Feb 2012

Liu Jia, Zhou Yongtao, Wang Chaodong, Wang Tao, Zheng Zheng, Chan Piu

Abstract excerpt

Parkinson's disease (PD) is a complex neurodegenerative disorder. Although the p.G2385R allele of leucine-rich repeat kinase 2 (LRRK2) has been recently reported as a common genetic variant that increases the risk for typical PD exclusively among Asian population, its genetic modifiers is yet to be studied. Brain-derived neurotrophic factor (BDNF) has been shown to play an important role in the survival of...

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Source

Identifiers

PMID: 21924942
DOI: 10.1016/j.parkreldis.2011.09.002

Genes

BDNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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