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Article

Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2007

Chen Chiung-Mei, Chen I-Cheng, Chang Kuo-Hsuan, Chen Yi-Chun, Lyu Rong-Kuo, Liu Yen-Tzu, Hu Fen-Ju, Chao Chih-Ying, Lee-Chen Guey-Jen, Wu Yih-Ru

Abstract excerpt

Both of environmental and genetic factors confer vulnerability to Parkinson's disease (PD). NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Brain derived neurotrophic factor (BDNF) deficiency may play a role in the pathogenesis of PD, as the surviving dopaminergic nigrostriatal...

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PMID: 17427185
DOI: 10.1002/ajmg.b.30476

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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