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Article

Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.

Experimental hematology - 1 Jan 2012

Anderson Nicole M, Berberovic Zorana, Berndl Elizabeth, Bailey Monica L, Flenniken Ann M, Osborne Lucy R, Adamson S Lee, Rossant Janet, Wang Chen, Minden Mark D, McNagny Kelly M, Paulson Robert F, Barber Dwayne L, Stanford William L

Abstract excerpt

The ability of random mutagenesis techniques to annotate the mammalian genome can be hampered due to genetic redundancy and compensatory pathways that mask heterozygous mutations under homeostatic conditions. The objective of this study was to devise a pharmacologically sensitized screen using the chemotherapeutic drug, 5-fluorouracil (5FU), to induce cytopenia. 5FU dose was optimized in the 129/SvImJ, C57BL/6J,...

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Identifiers

PMID: 21924221
DOI: 10.1016/j.exphem.2011.09.007
PMCID: PMC3341667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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