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ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level.

Blood cells, molecules & diseases - 1 Feb 2013

Brown Fiona C, Scott Nicholas, Rank Gerhard, Collinge Janelle E, Vadolas Jim, Vickaryous Nicola, Whitelaw Nadia, Whitelaw Emma, Kile Benjamin T, Jane Stephen M, Curtis David J

Abstract excerpt

Forward genetic screens have been performed in many species to identify phenotypes in specific organ systems. We have undertaken a large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify dominant mutations that perturb erythropoiesis in mice. Mutant mice that displayed an erythrocyte mean cell volume (MCV) greater than three standard deviations from the population mean were identified. Two of these...

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PMID: 23040355
DOI: 10.1016/j.bcmd.2012.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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