Article
ENU-mutagenesis: insight into immune function and pathology.
Current opinion in immunology - 1 Oct 2006
Cook Matthew C, Vinuesa Carola G, Goodnow Christopher C
Abstract excerpt
In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in approximately 30 coding mutations in male G1 mice, of which approximately 4 can be propagated to homozygosity in 3 generations. In recent years, large-scale screens of such G3 mice for phenotypes of interest to immunologists have revealed clues to the number of...
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