Article
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2004
Carpinelli Marina R, Hilton Douglas J, Metcalf Donald, Antonchuk Jennifer L, Hyland Craig D, Mifsud Sandra L, Di Rago Ladina, Hilton Adrienne A, Willson Tracy A, Roberts Andrew W, Ramsay Robert G, Nicola Nicos A, Alexander Warren S
Abstract excerpt
Genetic screens in lower organisms, particularly those that identify modifiers of preexisting genetic defects, have been used successfully to order components of complex signaling pathways. To date, similar suppressor screens have not been used in vertebrates. To define the molecular pathways regulating platelet production, we have executed a large-scale modifier screen with genetically thrombocytopenic Mpl(-/-)...
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