Article
Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models.
Disease models & mechanisms - 1 Jan 2013
Bakker Sietske T, de Winter Johan P, te Riele Hein
Abstract excerpt
Fanconi anaemia (FA) is a rare autosomal recessive or X-linked inherited disease characterised by an increased incidence of bone marrow failure (BMF), haematological malignancies and solid tumours. Cells from individuals with FA show a pronounced sensitivity to DNA interstrand crosslink (ICL)-inducing agents, which manifests as G2-M arrest, chromosomal aberrations and reduced cellular survival. To date, mutations...
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