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Article

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia.

Blood - 28 Nov 2013

Hobbs Catherine M, Manning Harriet, Bennett Cavan, Vasquez Louella, Severin Sonia, Brain Lauren, Mazharian Alexandra, Guerrero Jose A, Li Juan, Soranzo Nicole, Green Anthony R, Watson Steve P, Ghevaert Cedric

Abstract excerpt

The principal morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia rubra vera (PV) stems from thrombotic events. Most patients with ET/PV harbor a JAK2V617F mutation, but its role in the thrombotic diathesis remains obscure. Platelet function studies in patients are difficult to interpret because of interindividual heterogeneity, reflecting variations in the proportion of...

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Identifiers

PMID: 24085768
DOI: 10.1182/blood-2013-06-501452
PMCID: PMC3843237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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