Article
Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.
Journal of molecular biology - 28 Oct 2011
Li Alison Yueh, Lee Jaeyong, Borek Dominika, Otwinowski Zbyszek, Tibbits Glen F, Paetzel Mark
Abstract excerpt
The amino-terminal regulatory domain of cardiac troponin C (cNTnC) plays an important role as the calcium sensor for the troponin complex. Calcium binding to cNTnC results in conformational changes that trigger a cascade of events that lead to cardiac muscle contraction. The cardiac N-terminal domain of TnC consists of two EF-hand calcium binding motifs, one of which is dysfunctional in binding calcium....
Topics
- Binding Sites
- Cadmium
- Crystallography, X-Ray
- Deoxycholic Acid
- EF Hand Motifs
- Heart
- Humans
- Models, Molecular
- Molecular Conformation
- Mutagenesis, Site-Directed
- Mutation
- Protein Binding
- Protein Conformation