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Article

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.

Journal of molecular biology - 28 Oct 2011

Li Alison Yueh, Lee Jaeyong, Borek Dominika, Otwinowski Zbyszek, Tibbits Glen F, Paetzel Mark

Abstract excerpt

The amino-terminal regulatory domain of cardiac troponin C (cNTnC) plays an important role as the calcium sensor for the troponin complex. Calcium binding to cNTnC results in conformational changes that trigger a cascade of events that lead to cardiac muscle contraction. The cardiac N-terminal domain of TnC consists of two EF-hand calcium binding motifs, one of which is dysfunctional in binding calcium....

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Identifiers

PMID: 21920370
DOI: 10.1016/j.jmb.2011.08.049
PMCID: PMC4068330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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