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Article

Modulation of the picosecond dynamics of troponin by the cardiomyopathy-causing mutation K247R of troponin T observed by quasielastic neutron scattering.

Biochimica et biophysica acta. Proteins and proteomics - 1 Dec 2017

Matsuo Tatsuhito, Tominaga Taiki, Kono Fumiaki, Shibata Kaoru, Fujiwara Satoru

Abstract excerpt

Troponin (Tn), consisting of three subunits (TnC, TnI, and TnT), regulates cardiac muscle contraction in a Ca2+-dependent manner. Various point mutations of human cardiac Tn are known to cause familial hypertrophic cardiomyopathy due to aberration of the regulatory function. In this study, we investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain...

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Source

Identifiers

PMID: 28923663
DOI: 10.1016/j.bbapap.2017.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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