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Article

Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats.

Genes and immunity - 1 Feb 2012

Yokoi N, Hidaka S, Tanabe S, Ohya M, Ishima M, Takagi Y, Masui N, Seino S

Abstract excerpt

Although the MHC class II 'u' haplotype is strongly associated with type 1 diabetes (T1D) in rats, the role of MHC class II in the development of tissue-specific autoimmune diseases including T1D and autoimmune thyroiditis remains unclear. To clarify this, we produced a congenic strain carrying MHC class II 'a' and 'u' haplotypes on the Komeda diabetes-prone (KDP) genetic background. The u/u homozygous animals...

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Identifiers

PMID: 21918539
DOI: 10.1038/gene.2011.63
PMCID: PMC3308136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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