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Article

Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2005

Ueno Aito, Cho Suzanne, Cheng Lu, Wang Zhongying, Wang Bo, Yang Yang

Abstract excerpt

Polymorphism of MHC and MHC-linked genes is tightly associated with susceptibility to type 1 diabetes (T1D) in human and animal models. Despite the extensive studies, however, the role of MHC and MHC-linked genes expressed by T cells on T1D susceptibility remains unclear. Because T cells develop from TCR(-) thymic precursor (pre-T) cells that undergo MHC restriction mediated by thymic stroma cells, we...

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Share to beta 2-Microglobulin
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Immunologic

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Share to Mice, Inbred AKR

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Source

Identifiers

PMID: 16210629
DOI: 10.4049/jimmunol.175.8.5240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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