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Article

T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.

Genes - 1 Jun 2021

Mordes John P, Cort Laura, Liu Zhijun, Eberwine Ryan, Blankenhorn Elizabeth P, Pierce Brian G

Abstract excerpt

Genetic analyses of human type 1 diabetes (T1D) have yet to reveal a complete pathophysiologic mechanism. Inbred rats with a high-risk class II major histocompatibility complex (MHC) haplotype (RT1B/Du) can illuminate such mechanisms. Using T1D-susceptible LEW.1WR1 rats that express RT1B/Du and a susceptible allele of the Ubd promoter, we demonstrate that germline knockout of Tcrb-V13S1A1, which encodes the Vβ13a...

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Share to Autoimmunity
Share to Diabetes Mellitus, Type 1
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

Source

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Identifiers

PMID: 34205929
DOI: 10.3390/genes12060852
PMCID: PMC8227067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.PMID 34205929Read ↗

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