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Article

Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.

Diabetes - 1 Feb 2007

Yokoi Norihide, Hayashi Chihiro, Fujiwara Yuuka, Wang He-Yao, Seino Susumu

Abstract excerpt

The Komeda diabetes-prone (KDP) rat is an animal model of human autoimmune type 1 diabetes. We have previously shown that two major susceptibility genes, the major histocompatibility complex (MHC) RT1(u) haplotype and Cblb (Casitas B-lineage lymphoma b) mutation, are responsible for the development of diabetes in KDP rats, suggesting a two-gene model for development of the disease. To confirm the two-gene model,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Share to Proto-Oncogene Proteins c-cbl

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PMID: 17259398
DOI: 10.2337/db06-1027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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