Article
Influence on spontaneous tissue inflammation by the major histocompatibility complex region in the nonobese diabetic mouse.
Scandinavian journal of immunology - 1 Feb 2005
Lindqvist A-K B, Nakken B, Sundler M, Kjellén P, Jonsson R, Holmdahl R, Skarstein K
Abstract excerpt
We investigated the role of the major histocompatibility complex (MHC) region in the specificity of autoimmunity by analysing specifically the development of sialadenitis, but also insulitis, nephritis and autoantibody production in autoimmune-prone nonobese diabetic (NOD) mice where the MHC H2g7 haplotype had been exchanged for the H2q (NOD.Q) or H2p (NOD.P) haplotype. The exchange of H2 haplotype did not affect...
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